Research Project

Reducing racial disparities in lung cancer outcomes by decoding neighborhood contextual environment (RECODE)

Principal Investigator: Kim, Sage J
Start Date: 2021-05-06
End Date: 2026-01-31
Research Area(s): Cancer; Health Disparities
Funding Source: NIH/ NIMHD R01MD014839

Abstract

This project proposes to 1) examine mechanisms of neighborhood social, economic, and environmental risks for lung cancer incidence and stage at diagnosis, 2) to identify the relationship between neighborhood risks and PRMT6-mediated epigenetic changes, and 3) to explore the relationship between neighborhood risk and hair cortisol levels among high-risk individuals. Although the link between neighborhood context and lung cancer outcomes has been documented, little is known about specific mechanisms through which neighborhood context affects biological and behavioral risks for lung cancer outcomes. This study examines neighborhood contextual factors that may contribute to understanding epigenetic changes and lung cancer risk.